AlpHelix specializes in membrane-protein antigen design, antibody discovery and optimization. The in-depth structure-function study offered by AlpHelix greatly facilitates customer needs for developing high-quality therapeutic antibody leads targeting membrane proteins.

Based on our strengths in structural biology and AI-aided design, we can engineer membrane proteins outside their active sites while maintaining their natural fold, thereby improving the folding stability of these proteins, which are most suitable for therapeutic antibody discovery.

We also prepare membrane proteins in biased states by combining mutation engineering with liposomal and nanodisc-reconstitution, allowing for the discovery of functional antibodies specific for different states.

With our professional experience and rich proprietary database, we provide unique nucleic code optimization to achieve a balance between expression efficiency and folding accuracy. In addition, our expertise in quickly determining the detergent/lipid/protein molecular ratio speeds up the preparation of membrane proteins in the desired states.