Membrane proteins (MPs) are proteins that are embedded in the cell membrane or the membrane of an intracellular organelle...
Membrane proteins (MPs) are proteins that are embedded in the cell membrane or the membrane of an intracellular organelle...
Learn More >>More than 90% of the targets of therapeutic antibody drugs or immunotherapies are membrane proteins (MPs)...
More than 90% of the targets of therapeutic antibody drugs or immunotherapies are membrane proteins (MPs)...
Learn More >>The transmembrane proteins,typically hydrophobic in their membrane-embedded...
The transmembrane proteins, typically hydrophobic in their membrane-embedded regions...
Learn More >>Structural Biology
Historically, drug research related to membrane protein targets has been hampered by difficult protein expression and three-dimensional structure studies. Learn More >>Cell Engineering
Reporter cell lines play an important role in drug discovery owing to their high-throughput, reliable output, and cost-effectiveness. Learn More >>New Chemical Entity and Antibody Discovery
The MP targets, by engineering a small number of single point mutations outside of the ligand-binding pocket Learn More >>Bispecific Antibodies
Alphelix applies a versatile approach to directly generate common light chain bispecific antibodies by using yeast surface display of heterodimeric IgG-like bispecific antibody Learn More >>Functional Validation
Validation of drug candidates at the molecular cellular and animal levels Learn More >>AlpHelix provides services including large-scale overexpression, purification and analysis of difficult-to-express MPs, as well as three-dimensional structure determination, structure-based drug screening, and directed evolution of proteins. MPs covered by these services include: GPCRs, ion channels, transporters, transmembrane proteases (TPs), membrane receptors (other than GPCRs), and kinases.
Overexpression of Membrane Proteins and Purification
The data from Protein Data Bank show that membrane protein (MP) structures only account... Learn More >>Drug Discovery Based on Membrane Protein Reporter Cell Line
A reporter gene is a gene that encodes a protein or enzyme that can be detected, in other words, a... Learn More >>Drug Discovery and Optimization Based on X-ray Crystal Structures and Cryo-EM Single-particle Structures
The 3D structure of the drug-protein complex can precisely reveal how a drug binds and acts on... Learn More >>AlpHelix Biosciences is a high-tech biotech company that contributes to the discovery of innovative biopharmaceuticals. We focus on membrane proteins (including ion channels, transporters, and GPCRs) and challenging Kinases. The main services of AlpHelix include overexpression and purification of membrane proteins, biophysical and biochemical characterization of these proteins, high-throughput ligand/drug screening using report cells, monoclonal/bispecific antibody discovery and engineering based on yeast surface display of full-length IgG, structure determination using X-ray crystallography and cryo-electron microscopy, and drug discovery and optimization based on the protein structures.
AlpHelix has built advanced technology platforms such as "structural biology," "cell engineering," "antibody and new chemical entity discovery," and "functional verification," and has established cooperative relationships with many well-known pharmaceutical companies and biotechnology companies to conduct research and development collaborations on small molecule, antibody, and peptide drugs targeting GPCRs, ion channels, and transporters.
Learn More >>For more information about our technology and services, please contact us.
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